The Game of Lice is episode 33a of Edward and Eric. It premiered on Kids' WB on February 5, 2000.
- Andrew Rannells as Edward, The Narrator and B. Roadcast
- Josh Peck as Eric
- Dee Bradley Baker as Old Man Esmond, Wi Tu Lo, and Lice
- Veronica Taylor as Carver
- Mike Pollock as Principal Walker
- Edward Felker as Stanley and Walt Walker
- Gary Sauls as Joey and Constantinos
- Dan Green as Dallas
- The title is a reference to the popular board game, The Game of Life, which is sometimes simply called Life.
- The title card also resembles the logo of said game.
- This episode is available to watch on the Season 3 Volume 1 box set, and on the Misadventures in the West DVD outside of the United States.
- Esmond doesn't even have hair to begin with, yet ironically, the conflict of the episode started from when he tried to "comb".
- The title card track is basically Tentically Speaking albeit high-pitched.
- This episode premiered during the Kids' WB Snow Jam.
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